Protein Details: Glycine receptor subunit alpha-3

Protein ID

ICDB_Pro_1358

Protein Name

Glycine receptor subunit alpha-3

Gene Name

Glra3

Organism

Mus musculus (Mouse)

Length

464 amino acids

AlphaFoldDB

AF-Q91XP5-F1-model_v4.pdb

Function

Sequence

MAHVRHFRTLVSGFYFWEAALLLSLVATKETNSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDTDDEVRESRFSFTAYGMGPCLQAKDGVVPKGPNHAVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

225;227;235-240;248;294

Disease

Location

Detected in brainstem; also in neurons that control rhythmic breathing. Detected in superficial laminae of the dorsal horn of the thoracic spinal cord. Detected in dentate gyrus in hippocampus; especially in stratum granulare. Detected in the inner plexiform layer in the retina (at protein level). Detected in midbrain; thalamus; brain cortex; hippocampus; and at lower levels in cerebellum.